During the earthquake, the failure of structure starts at points of weakness. As irregularities along the height of buildings are one of the major reasons of failures of structures during earthquakes. The object of the present work is the study of behaviour of multistorey building against the earthquake load by introducing vertical irregularities. The response has been compared on the basis of parameters like storey drift and lateral displacement in various seismic zones. Observation shows that for all the frames considered, the drift values follow a similar path along storey height with maximum value lying somewhere near the Eleventh to fifteenth storey. And from drift perspective, frame 1, 2 and 3 are within permissible limits in high intensity seismic zones although at some storeys frame 2 and 3 exceeds marginally. But frame 4 in zone V exceeds the permissible limits largely after tenth storey. In zone II and III all the frames are within permissible limit, hence there is no requirement of shear wall in these zones. And from displacement perspective, in zone II only, all the frames are within permissible limit. In zone III frame 1, 2 and 3 are in permissible limit but frame 4 requires shear wall to control the limit. In zone IV only frame 1 is within permissible limit, all other exceeds limits largely. And in zone V all the frames exceeds largely. Keywords: Storey drift, STAAD.Pro, Lateral, Displacement, Irregular, Earthquake