Uric acid is commonly associated withhypertension; recent experimentaland clinical studies suggest that uric acid could have a contributory role inthe pathogenesis of elevated blood pressure. Individuals at risk for developinghypertension and cardiovascular disease, frequently have evidence for asystemic inflammatory response, often marked by elevations of C-reactiveprotein (CRP) in their blood. Elevated levels of CRP have emerged as one of themost important predictors of myocardial infarction, stroke, and vascular death,with prognostic value exceeding that of LDL cholesterol.
Aim: To evaluate, serum uric acid and CRP levels in Sudanese hypertensivepatients in Khartoum state.
Material and methods: 100 subjects in the age group of25-60 years, divided into two groups ofhypertensive and control healthynormotensive group. (54) Patients suffering from hypertension and (46) ages matched non hypertension subjects, who were volunteered to be included in the study.Blood samples were collected in plain container for estimation of Serum C-RP and uric acid levels, Serum CRPlevels were detected (qualitatively) using latex agglutination method (Spinreact Kit; 2016). Uricacid was estimated by quantitative commercial kit method(on AutoanalyzerMindray. BS200). Venous blood sample wasdrawn from all subjects, allowed to clot at room temperature for 1–3 hours and serum wasseparated by centrifugation for 15 minat 3000 r. p. m. Data wereanalyzed using statistical package for the social sciences (SPSS).
Result:The patients of hypertensionunder study comprised of 51.9% males and 48.1% females while the control comprised of 52.2% males and 47.8% females, the agerange between 25 years to 60 years. Uric acid levels were high in66.7% of patients and normal in33.3 % of patients. However uric acid levels observed withinnormal range in all normotensivesubjects (control). CRP in 63 % of patients was positive while 37 % were negative and allcontrol was negative. There was strong significant positive correlation betweenuric acid and CRP with P- value 0.000.
Conclusion: Serum uricacid levels were found higher in hypertensive patients than in healthyindividuals. Serum CRP in hypertensive patients shows higher percentage than inhealthy individuals.